Among these genes, the most overexpressed in platelet-educated cancer cells are those encoding proteins involved in cancer progression and metastasis, including SERPINE1 (358%), MMP2 (297%), MMP10 (214%), TIMP1 (187%), FN1 (166%), TMPRSS4 (146%) and RHOC (102%) (Table 1). Here, SERPINE1 is linked to cancer.