Moreover, several studies demonstrated that FN1 can activates different signaling pathways such as focal adhesion kinase (FAK), SNAIL-related zinc-finger transcription factor (SLUG), signal transducer and activator of transcription 3 (STAT3), and ERK/MAP to trigger EMT and increase the metastatic potential of the cancer cells [50,52–55]. Here, PTK2 is linked to cancer.