In contrast to WT mice (with 50% mortality), mortality was 100% in APN-, AdipoR1-, and AdipoR2-deficient mice, with mortality beginning on day 2 post-infection and reaching 100% by day 6 p.i. (Fig 1B), with extensive lung hyphal growth and peri-bronchoalveolar inflammation (Fig 1C) and increased fungal burden as measured by qPCR of fungal DNA (Fig 1D) and image quantification of fungal GMS staining (Fig 1E), most significantly in APN- and AdipoR1-deficient mice. The gene discussed is ADIPOR2; the disease is infection.