In a resting state, a higher percentage of APN-deficient AMs were CD38+ and lower percentage were Egr2+ when compared to WT (Fig 2C and 2D), while after 10 hours of infection with A. fumigatus, percentages of both CD38+Egr2- and CD38+Egr2+ cells increased, with no change in CD38-Egr2+ cells (Fig 2C and 2E). Here, EGR2 is linked to infection.