Anti-mutated citrullinated vimentin (anti-MCV) antibodies exhibit diagnostic accuracy comparable to RFs and ACPAs, positioning them as valuable markers for RA diagnosis Additionally, elevated anti-MCV levels have been associated with the presence of extra-articular manifestations and have shown a good predictive value of disease activity at 24 months in early RA [24,25,26]. The gene discussed is VIM; the disease is rheumatoid arthritis.