MBDA test is a tool that evaluates RA inflammation by measuring 12 serum protein biomarkers, including IL-6, TNF receptor type 1 (TNFR1), vascular cell adhesion molecule-1 (VCAM-1), epidermal growth factor (EGF), vascular endothelial growth factor A (VEGF-A), YKL-40, matrix metalloproteinases (MMP-1 and MMP-3), CRP, serum amyloid A (SAA), leptin, and resistin [72]. This evidence concerns the gene CRP and rheumatoid arthritis.