This model includes resting heart rate (>110 bpm), underweight (BMI < 18 kg/m2), respiratory rate (>28/min), first 24 h urine output (<0.5 mL/kg BW/hour), peripheral O2 saturation (<90%), systolic blood pressure during admission (<90 mmHg), urea nitrogen (>50 mg/dL), reduced ejection fraction (<40%), timing of primary percutaneous coronary intervention (door-to-balloon time >2 h), age (>70 years old), sex (women), anemia (Hb < 10 g/dL), and elevated NT-proBNP (>1500 pg/mL) as factors for risk adjustment. This evidence concerns the gene NPPB and anemia (phenotype).