Another substance secreted by skeletal muscle that deserves to be highlighted is IL-6 since, despite being considered a pro-inflammatory factor, it induces anti-inflammatory responses such as an increase in IL-10 and IL-1ra and stimulates the secretion of peptides like glucagon 1 (GLP-1), which may act in the repair of the intestinal mucosa after damage related to the pathogenesis of IBD [10]. Here, IL6 is linked to irritable bowel syndrome.