METTL16, an m6A methyltransferase discovered recently, operates independently from the METTL3/14 complex and holds significance in a range of cancers, including hepatocellular carcinoma [29], pancreatic ductal adenocarcinoma [30], epithelial ovarian cancer [31], breast cancer [25], and cholangiocarcinoma [32]. Here, METTL3 is linked to pancreatic ductal adenocarcinoma.