APOE and Alzheimer disease: Cholinergic drugs tend to reverse EEG “slowing,” supporting this hypothesis.20,74 Anticholinergic drugs (e.g., scopolamine), which block the stimulation of post-synaptic receptors, cause EEG “slowing”.20,74,75APOE-ε4 positive AD patients are characterized by more severe cholinergic deficits than patients with a neutral APOE genotype.76