SERPINC1 and AL amyloidosis: Transthyretin, light chains, and the acute phase proteins in amyloid A amyloidosis, directly affects the coagulation cascade during coagulation initiation and fibrinolysis regulation [65]: in patients with AL amyloidosis, impairment of the thrombin-antithrombin pathway (lower antithrombin III activity, reduced heparin binding) [72], nephrotic syndrome leading to glomerular loss of natural anticoagulant factors (antithrombin III, protein S), and increased synthesis of procoagulant factors (factor V, VII, fibrinogen) [73] play a pathogenic role in the hypercoagulable state reported in CA.