GLP1R and Obesity: Certainly, our study did not address the underlying pathology of worsened outcomes in the obese pediatric cohort, which would provide further and more tailored guidelines on how to treat sepsis in obese pediatric patients, but there is a report that obesity drug glucagon-like peptide 1 receptor (GLP1R) agonists may be associated with lower mortality in sepsis [48], suggesting a potential mechanism.