Nevertheless, through NGS analysis on ctDNAs extracted from blood samples of patients affected by different thyroid tumor types, it has been observed that the large majority of patients presented one or more genomic alterations and TP53 mutation was the most frequent in all thyroid tumor types, followed by BRAFV600E, RAS, RET, ALK and NTRK with variable frequency according to the type of tumors taken into account [166]. This evidence concerns the gene RET and thyroid tumor.