Blood creatinine levels are associated with the blood biomarkers for neurodegeneration, including neurofilament light chain(NFL) (Stocker et al. 2023), amyloid protein (Arvanitakis et al. 2002), and phosphorylated tau (Stocker et al. 2023), as well as the risk of dementia (Wu et al. 2022). The gene discussed is NEFL; the disease is dementia.