Frailty has been associated with deficiency and impaired rhythmicity of glucocorticoid secretion[52–54], androgen deficiency, GH/insulin-like growth factor 1 (IGF-1) deficiency[55, 56], diabetes mellitus, and the metabolic syndrome [48, 55]. Here, GH1 is linked to hyperinsulinemic hypoglycemia, familial, 4.