Patients with CNS progressed to kidney failure earlier than those with infantile NS regarding NPHS1 variants, as well as when all non-NPHS1 variants were combined (31.0 vs. − months; P = 0.025, and 1.0 vs. 15.0 months; P < 0.001, respectively) (Fig. 2c and d). This evidence concerns the gene NPHS1 and kidney failure.