Other predictive parameters include high-sensitivity C-reactive protein (hs-CRP) and albumin ratio, as Ren Y. et al. proved to be an independent marker of the reappearance and progression of HCC [58], programmed cell death protein-1 (PD-1), microRNAs, and proteins in urinary exosomes, Model for End-Stage Liver Disease (MELD) scores, presence of fibrosis or cirrhosis, the time elapsed since curative cancer treatment, history of multiple treatments, and previous recurrences are also associated with HCC reappearance [27,59,60]. This evidence concerns the gene PDCD1 and Cirrhosis.