In particular, we observed six ductal carcinomas in situ (three upgrades from ADH and three upgrades from FEA), seven invasive ductal carcinomas (two upgrades from ADH, two upgrades from FEA, one upgrade from LN and two upgrades from PL) and one invasive lobular carcinoma (upgrade from LN). The gene discussed is AVP; the disease is ductal breast carcinoma in situ.