TNF and stroke disorder: On the other hand, the persistence of high TNF-a levels after the second atherothrombotic stroke showed a ROC curve of 0.88 (95% CI: 0.85.0.91) with an optimal cut-off of >24 pg/mL (Figure 2C), which was independently associated with atherothrombotic stroke recurrence (adjusted OR 21.26; 95% CI: 12.42–37.59).