Later, the same research group found that I3C decreased the CXCR2-expressing neutrophils and reduced the CCL2 (MCP-1) protein levels of broncho-alveolar lavage fluid in LPS-induced ARDS, possibly due to AhR activation that regulates immune cells transferring to the lung in ARDS [266]. The gene discussed is CXCR2; the disease is acute respiratory distress syndrome.