I3C in combination with chlorogenic acid (CGA) against diet/chemical-induced nonalcoholic steatohepatitis (NASH) showed reduced hepatic lipid accumulation, prevented HSC activation and fibrosis, decreased hepatic CD68-positive macrophages, cleaved caspase -3, and lowered malondialdehyde levels in NASH. The gene discussed is CASP3; the disease is metabolic dysfunction-associated steatohepatitis.