To assess whether FACT is also required to stabilize CCAN at the kinetochore, we used a previously established chronic myeloid leukemia K562 cell line where SSRP1 is endogenously tagged with a dTAG degron for rapid degradation (Žumer et al., 2024). This evidence concerns the gene SUPT16H and chronic myelogenous leukemia, BCR-ABL1 positive.