Our results indicated that PEDV mostlyinduces dormant infections in CD4+ T cells and increases the expressionof integrin α4β7, which in turn enhances their migration to the gut.Furthermore, we determined the specific molecular process through which PEDVtriggers the activation of the integrin α4β7-mediatedRho-GTPase-Cofilin signaling pathway. The gene discussed is CFL1; the disease is infection.