Any grade: Elevated CPK (60%), anemia (56%), dry skin (56%), acneiform/maculopapular rash (58%/52%), vomiting/diarrhea (44%/54%), decreased ejection fraction (38%), peripheral edema (26%)Grade ≥3: Elevated CPK (10%), maculopapular rash (10%), diarrhea (4%), decreased ejection fraction (2%), headache (2%), gastric hemorrhage (2%). This evidence concerns the gene PIK3C2A and anemia (phenotype).