Any grade: Weight gain (49%), Anemia (40%), Creatinine inc. (40%), nausea (35%), constipation (30%), ALT inc. (28%), AST inc. (26%), Neutrophil count dec. (35%), White blood cell dec. (21%), Vomiting (21%)Grade ≥ 3: weight gain (16%), ALT inc. (5%), Neutrophil count dec (26%), White blood dec. (5%), Fracture (5%). This evidence concerns the gene GPT and anemia.