After selecting SNPs with genomic significance and clumping for LD, 95, 11, 22, 8, 7, 13, 4, 4, and 17 instrumental variables were extracted to perform MR analysis for ALL, ASXL1, DNMT3A, GNB1, JAK2, PPM1D, SF3B1, SRSF2, TET2, respectively. Here, DNMT3A is linked to acute lymphoblastic leukemia.