PBRM1 and colorectal cancer: Several other aggressive malignancies also harbor PBRM1 defects, including 11-59% chordomas, 12-23% cholangiocarcinomas, 7-20% mesotheliomas, 12% endometrial carcinomas, 3% non-small cell lung cancers (NSCLC), and 5% colorectal cancer (CRC)8.