PBRM1 and colorectal carcinoma: After co-culturing with sgPBRM1-HCT116 cells for 72 h, the number of CD8+ T and NK cells in PBMCs was significantly increased compared to that in the NC group (Figure 3G), demonstrating that PBRM1 deficiency in CRC cells promotes chemotaxis of CD8+ T and NK cells in the mesenchyme.