Furthermore, we dissected the contribution of PBRM1 deletion in CRC by regulating inflammatory factors, such as CCL5 and CXCL10 chemotaxis, and activating cytotoxic T cells and killer NK cells, which express NKG2D in the tumor microenvironment through activation of the NF-κB signaling pathway. The gene discussed is PBRM1; the disease is colorectal carcinoma.