In an in situ tumor model constructed in BALB/C mice (Figure 7A), the application of ACBL1 in the PBRM1 wild-type group yielded results similar to those of the PBRM1 mutant group, where both promoted immune sensitization to PD1 antibodies in mice (Figure 7B and Figure 7C). Here, PBRM1 is linked to neoplasm.