After 42 days of PD-1 antibody treatment (200 μg/ip) or the PBRM1-ACBL1 inhibitor (100 μg/ip) given to BALB/c mice, as shown in Figure S9, the in situ tumor volume of the cecum of mice grown with CT26-gPBRM1-1 was not significantly changed compared with the control group; however, the tumor volume in the PBRM1 mutant group was considerably reduced after PD-1 antibody treatment. The gene discussed is PBRM1; the disease is neoplasm.