These findings are consistent with previous studies reporting FOS induces apoptosis in leukemia and lymphoid cells 79-81, and align with our observation that ZNF217 depletion induces apoptosis in B-ALL cells (Figures 2G-2I and S2K-S2L), reinforcing the role of FOS as a tumor suppressor suppressed by ZNF217 in B-ALL. Here, FOS is linked to precursor B-cell acute lymphoblastic leukemia.