ZNF217 and acute lymphoblastic leukemia: Employing the Model-based Analysis of Genome-wide CRISPR-Cas9 Knockout (MAGeCK) algorithm, our focused CRISPR screen revealed ZNF217 (encoding Zinc Finger Protein 217) as the top-ranked essential gene in both KOPN-8 and SUP-B15 B-ALL cells (Figure 1D-1F and Figure S1H-S1J).