Amongst these core-enriched genes (Figure 6H), FOS (Fos proto-oncogene) has been reported to induce apoptotic cell death and/or cell-cycle arrest across various cancer types, including colon, prostate, nasopharyngeal cancer, and myeloid leukemia, as well as activating apoptosis in mouse lymphoid cells 74-79, but its role in B-ALL is still unclear. Here, FOS is linked to precursor B-cell acute lymphoblastic leukemia.