ZNF217 and acute lymphoblastic leukemia: As expected, ZNF217 knockdown (KD) using short hairpin RNAs (shRNAs) also resulted in profound growth inhibition in both human B-ALL PDX cells (Figure 2E-2F and Figure S2C-S2F) and cell lines (Figure S2G-S2J), akin to the effects observed with CRISPR KO.