SUV39H1 and graft versus host disease: Notably, while Jain et al. observed no signs of malignant expansion or transformation in SUV39H1-knockout CAR-T cells during a 200-day monitoring period 80, Niborski found that when Suv39h1-KO T cells were transplanted into B6xDBA/2 F1 recipient mice, they experienced more severe graft-versus-host disease (GvHD) compared to those receiving WT B6 bone marrow.