FLT3 gene mutations D835Y (c.2503G>T)/H (c.2503G>C)/V (c.2504A>T)/F (c.2503G, c.2504A>c.2503T, c.2504T), found in more than one-third of AML cases, may influence the interaction with clinically approved AML inhibitors used in treatment 24. This evidence concerns the gene FLT3 and acute myeloid leukemia.