Suppression of GVHD in mice treated with i35-Bregs also correlates with decrease of proinflammatory lymphocyte subsets that produce IFN-γ (Th1) or both IL-17A and IFN-γ (Th17-DP) in the liver and spleen (Figure 2C and Figure S2A). The gene discussed is IFNG; the disease is graft versus host disease.