Building on our findings that IQGAP1 mediates the selective incorporation of pY105-PKM2 into sEVs and enhances drug resistance in recipient cells, we investigated whether IQGAP1 and pY105-PKM2 act synergistically to promote stemness and malignant progression in NSCLC. The gene discussed is IQGAP1; the disease is non-small cell lung carcinoma.