The OVA-specific CD8+ T cells co-cultured with the CD19@NP/17-DMAG plus imatinib-pretreated B-ALL cells exhibited greater proliferation and activation than those co-cultured with the 17-DMAG plus imatinib-pretreated B-ALL cells (Figure 6H-K, Figure S6G-H). This evidence concerns the gene CD8A and acute lymphoblastic leukemia.