Average summed [18F]FMPEP-d2 images demonstrate the loss of CB1 signal in 4-month female AppNL-G-F mice, no genotype change at 8-months, and reduced availability in AppNL-G-F mice of both sexes at the 12-month late-stage AD pathology (Figure 1B). The gene discussed is CNR1; the disease is Alzheimer disease.