The prognostic role of LIPI for OS was statistically significant in the subgroups of patients with no smoking history, no alcohol consumption history, high CEA, high CA19-9, obstructive jaundice, 2-3 organ transplantations, liver metastases, and chemotherapy regimens that did not include G. These findings highlight the potential of LIPI as a valuable prognostic tool in predicting OS for PDAC patients undergoing chemotherapy. This evidence concerns the gene CEACAM5 and Jaundice.