Although we had identified shared diagnostic gene for IBD and psoriasis through bioinformatics methods, it was not clear the specific comorbidity mechanism of AQP9, and the developmental sequence of the alteration of the expression of AQP9 was unclear whether it is prior to the occurrence of the two inflammatory diseases or secondary to the two inflammatory diseases, as well as whether AQP9 was involved in the NF- kappaB pathway in these two diseases and the regulatory mechanism thereof were still unclear, so further research still requires rigorous experimental verification. This evidence concerns the gene AQP9 and inflammatory bowel disease.