The expression of Arg1 was correlated with the higher inflammatory score in IBD patients.36 Furthermore, the expression of Arg1 was upregulated in both intestinal epithelial cells and myeloid cells,36 and the inhibition of Arg1 was effective for colitis treatment in a dextran sodium sulfate-induced colitis model in mice.37 The abundance of Arg was also enriched in the IC group. Here, ARG1 is linked to colitis.