IL6 and Anxiety: Although the increase in IL-6 levels did not reach statistical significance, it was still noticeably elevated, suggesting its potential involvement in IC-related inflammatory processes.6 In contrast, L. lactis LL95 orally administrated to mice improved depressive- and anxiety-like behavior.39 Ma et al. found that the oral administration of L. lactis E001-B-8 in mice promoted the production of 5-HT (serotonin) and alleviated depressive and anxiety-like behaviors in response to chronic unforeseeable mild stress stimulation.