Fu et al. reported that hsa_circ_0046523 was beneficial for an immunosuppressive tumor microenvironment by propelling the apoptosis and exhaustion of CD8+ T cells, inhibiting CD8+ T cell function, lowering the secretion of immunosuppressive cytokines interleukin-10 and TGF-β, and lessening the secretion of immune effector cytokines interferon-gamma and IL-2 among among peripheral blood mononuclear cells 129. The gene discussed is CD8A; the disease is neoplasm.