The IL-1β (normal: 2.33±1.81 pg/ml, DKD: 2.30±0.99 pg/ml, low-dose: 3.50±2.07 pg/ml, intermediate-dose: 5.42±9.21 pg/ml, high-dose: 1.00±0.31 pg/ml) (Fig. 2C) and TNF-α (normal: 3.06±4.78 pg/ml, DKD: 4.19±3.64 pg/ml, low-dose: 9.63±7.69 pg/ml, intermediate-dose: 7.08±6.84 pg/ml, high-dose: 0.05±0.09 pg/ml) (Fig. 2D) levels significantly differed between the high-dose group and the DKD group. This evidence concerns the gene TNF and diabetic kidney disease.