14 thyroid cancer-related genes (AKT1, BRAF, CTNNB1, EIF1AX, HRAS, KRAS, NRAS, PAX8, PIK3CA, PTEN, RET, TERT, THADA, and TP53) and 21 types of gene rearrangements occurring in thyroid cancer (ACBD5, AFAP1L2, ALK, ATG10, BRAF, CALM2, CCDC6, ERC1, ETV6, FLNC, FMNL2, KIAA1217, KIAA1594, KIF20B, NCOA4, NTRK3, PAK1, PAX8, PIBF1, PPAR γ, PXK, RALGAPA2, RET, SND1, and STRN). The gene discussed is PIK3CA; the disease is thyroid gland carcinoma.