CD4 and neoplasm: In breast cancer samples characterized by cluster clusters consisting of 13 core genes, the infiltration of M0 macrophages, M1 macrophages and CD4+ memory T cells was significantly upregulated, whereas the infiltration of monocytes, resting dendritic cells and resting mast cells was significantly downregulated, which revealed a correlation between the core cluster genes and the immune microenvironment of breast cancer, the DHIE may act by simultaneously affecting the proportion of infiltration or function of some types of immune cells in the tumor microenvironment (Figure 6B).