In liver cancer, serine beta-lactamase-like protein inhibits the ferroptosis of hepatocellular carcinoma cells by regulating the p53/HSPA8 axis (Zeng et al., 2024); and aristolochic acids suppress ferroptosis via modulation of the p53/GADD45A/NRF2/SLC7A11 pathway (Hou et al., 2024). Here, TP53 is linked to hepatocellular carcinoma.