NLRP3 and myelodysplastic syndrome: Additionally, in MDS patients, the activation of NLRP3 inflammasomes is a redox-dependent, hallmark feature that leads to clonal expansion and pyroptosis (Sallman and List, 2019; Sallman et al., 2016), which results in increased ROS levels (Montalban-Bravo et al., 2020; Grignano et al., 2020).