In addition, some scholars have investigated the antitumor activity of chelerythrine from Z. bungeanum and discovered that it could reduce p-FAK expression, thereby altering the cytoskeletal structure and inhibiting hepatocellular carcinoma by downregulating MMP-2/9 expression through the PI3K/AKT/mTOR signaling pathway (Zhu et al., 2018). Here, AKT1 is linked to hepatocellular carcinoma.