CXCL12 and neoplasm: CAFs are a heterogeneous group of fibroblasts that promote tumor growth in several ways: through the remodeling of the extracellular matrix (ECM) to promote metastasis, through interactions with cancer cells to promote proliferation, and through the release of cytokines and chemokines that promote tumor invasion through the TME.[59,61,80] We identified seven clusters of CAFs, which we categorized into ECM-related CAFs, myofibroblasts, CXCL8 CAFs, and CXCL12 CAFs.