EREG and neoplasm: The IL1β cluster showed similarity with VCAN- and EREG-expressing tumor-associated macrophages (TAMs) associated with angiogenesis identified in a pan-cancer macrophage atlas.[36] This cluster was also found to be enriched for inflammatory genes, including the aforementioned IL1β, which has been shown to promote drug resistance through induction of ICAM1 on tumor cells[37], IL6 and IL10, which have been shown to promote immunosuppression through induction of Tregs[38], cytokine-cytokine receptor interactions, and EMT (Fig 3c,d).