C3 and systemic lupus erythematosus: Lastly, in the differential between ANA- SLE and AHV (Figure 2F), TC4d (AUC: 0.75) significantly outperformed anti-Smith (0.42, p < 0.01) and nearly reached significance for superior performance against anti-dsDNA (0.51, p = 0.06) and C3 (0.50, p = 0.05).