MIF and myocardial infarction: Moreover, studies attempting to dissect the opposing functions of MIF in MI reported that the protective effects were mediated via MIF and CXCR2 signaling in cardiac tissue-resident cells, which promoted survival and myocardial healing, whereas the detrimental effects of MIF were dependent on leukocyte-derived MIF and cardiac fibroblast-derived CCL2 to promote myocardial inflammatory infiltration (106, 156–159).