demonstrated that neutrophils identify pathogen-associated molecular patterns (PAMPs) via TLR2, which actives NF-κB signaling and the subsequent release of pro-inflammatory factors (48), and that artesunate treatment could reverse the increase in the proportion of pro-inflammatory subsets by inhibiting TLR2 expression while alleviating sepsis-induced liver injury in mouse models. The gene discussed is TLR2; the disease is Sepsis.