In high-grade gliomas, soluble neuroligin-3 (NLGN3) secreted by neurons and oligodendrocyte precursor cells interacts with receptors on tumor cell surfaces, activating the PI3K-mTOR signaling pathway that governs cell proliferation and survival, thus facilitating tumor growth and metastasis (108). The gene discussed is NLGN3; the disease is central nervous system cancer.