For instance, heat-induced activation of hypoxia-inducible factor 1 (HIF-1), a key transcription factor in oxygen homeostasis, along with its downstream targets, such as vascular endothelial growth factor A (VEGF-A) and 3-phosphoinositide-dependent protein kinase 1 (PDK1), leads to improved tumor vascularization and oxygenation (135, 136). This evidence concerns the gene VEGFA and neoplasm.