We also found that M.tb H37Ra infection could promote the activation of NF-κB (Supplementary Figure 4A, B), and the phosphorylation of NF-κB in THP-1 cells, but the phosphorylation level of NF-κB in THP-1 cells was significantly decreased when treated with PP (Supplementary Figure 4B). The gene discussed is NFKB1; the disease is infection.