- While, scheme 2 comparison showed that plasma levels of GM-CSF and IL-2 did not vary significantly between S. mansoni-infected children with or without liver fibrosis groups (Figures 3C, G, K) suggesting a lack of association of the plasma levels of these cytokines with the onset/progression of liver fibrosis during S. mansoni infection. Here, CSF2 is linked to Hepatic fibrosis.