In the article, folic acid-selenium nanoparticles (FA-SeNPs) were designed as a cancer-targeted nanodrug delivery system for ruthenium polypyridine (RuPOP). These nanoparticles can enter the cytoplasm in a time-dependent manner, facilitating long-term drug release under acidic conditions. The high expression of folate receptors (FAR) in cancer cells significantly enhances the uptake of FA-SeNPs, thereby inhibiting the expression of ABC family proteins and overcoming multidrug resistance in hepatocellular carcinoma (HCC). Here, ABCB6 is linked to hepatocellular carcinoma.