In CRC, chemokines (e.g., CXCL1/2) and cytokines (e.g., IL-8, and TGFβ) (35–37) are also involved in regulating neutrophil enrichment to the TME and facilitating their polarization towards TAN2 phenotype, while IL-22 plays a role in recruiting beneficial neutrophils (38). This evidence concerns the gene TGFB1 and colorectal carcinoma.