The combination of the glutaminase inhibitor CB-839 and 5-fluorouracil induces IL-8 expression in PiK3CA-mutated CRC cells, attracting neutrophils to tumor tissues, inducing NET formation and releasing Cathepsin G. Cathepsin G enters tumor cells through the cell surface protein RAGE, leading to mitochondrial translocation of pro-apoptotic BAX and triggering apoptosis in tumor cells (60). The gene discussed is PIK3CA; the disease is neoplasm.