Tumor TGF−β is associated with shorter EFS (121); it may be produced under MSC-NB cell-monocyte interaction, inducing an amplifying loop, where TGF-β stimulates the production of IL-6 and sIL-6Rα, protecting TAMs from spontaneous death and, in turn, promoting further TGF-β production (111). The gene discussed is TGFB1; the disease is neoplasm.