MYCN silencing in NB cell lines enhances IFN-γ activity, promotes Th1-recruiting chemokines (CXCL9 and CXCL10), increases T cell infiltration (39) and expression of ligands (MICA, ULBPs and PVR) of NK cell activating receptors leading to increased cytotoxic activity (63). This evidence concerns the gene IFNG and neuroblastoma.