When we studied the polymorphisms of CYP1A1 (rs1048943) in response to chemotherapy, we observed that CYP1A1 variant allele showednegative association with peripheral neuropathy in BC-P when treated with paclitaxel based chemotherapy (OR=0.35, 95% CI: 0.15-0.84;p=0.019). The gene discussed is CYP1A1; the disease is breast cancer.