It has been also evident fromearlier findings that the polymorphisms of majority of cytochrome genes are associated with therapeutic failure and chemotherapy inducedsevere toxicity reactions [11, 14-15].Some of the earlier studies provided an association of CYP1A1*2A, CYP1A1*2C, CYP1B1*3 and CYP1B1*4-polymorphisms with platinum basedchemotherapy response in lung cancer [16-17]. The gene discussed is CYP1B1; the disease is lung cancer.