The results also showed that CYP1B1 (G>C) polymorphisms showed significantnegative association with ER/PR HR-S of breast cancer patients (OR=0.53, 95% CI: 0.29-0.94; p=0.031) whereas the genotype distributionof other genotypes showed no association with ER/PR or Her2 hormone receptors respectively. The gene discussed is CYP1B1; the disease is breast cancer.